Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC025
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-12-29 16:39
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tblMadopar 1/2,1/4.1/2,1/4 old patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 34 individuals with a value less than 0.67 were subsequently diagnosed with PD. That is, 80.95% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.67 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 25, 'TN': 21, 'TP': 17, 'FP': 9}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 13, 'TN': 11, 'TP': 29, 'FP': 19}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 41, 'TN': 30, 'TP': 1, 'FP': 0}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 5, 'TN': 3, 'TP': 37, 'FP': 27}

Test Battery Details

Circle

numCircles 9
timePerCircleMean 34.4978
timePerCircleCoV 0.103449
timePerCircleSlope -0.0171412
meanError 1.74644
tremorFreq 6.05469
tremorRelPower 28.3008
tremorGyroAmpMean 0.0172931
tremorGyroAmpSlope -0.000363667
tremorGyroAmpCoV 0.602038
tremorCoordAmpMean 0.02331
tremorCoordAmpSlope 0.000466972
tremorCoordAmpCoV 0.391916
tremorAccAmpMean 0.029777
tremorAccAmpSlope 5.19447e-05
tremorAccAmpCoV 0.240988
tremorPcRelVar 0.62007
tremorPcX 0.453289
tremorPcY -0.891364

Circle Segment 1

Duration 34.04 s, Accuracy Estimate 1.031 (lower is better)

Circle Segment 2

Duration 41.64 s, Accuracy Estimate 1.161 (lower is better)

Circle Segment 3

Duration 31.64 s, Accuracy Estimate 1.27 (lower is better)

Circle Segment 4

Duration 37.76 s, Accuracy Estimate 1.612 (lower is better)

Circle Segment 5

Duration 34.44 s, Accuracy Estimate 1.811 (lower is better)

Circle Segment 6

Duration 34.48 s, Accuracy Estimate 1.818 (lower is better)

Circle Segment 7

Duration 29.4 s, Accuracy Estimate 2.099 (lower is better)

Circle Segment 8

Duration 34.96 s, Accuracy Estimate 2.149 (lower is better)

Circle Segment 9

Duration 32.12 s, Accuracy Estimate 2.767 (lower is better)

Spiral

numSpirals 2
timePerSpiralMean 71.22
timePerSpiralCoV 0.0980934
timePerSpiralSlope -0.138725
meanError 3.60768
tremorFreq 6.54297
tremorRelPower 23.0273
tremorGyroAmpMean 0.0305168
tremorGyroAmpSlope -0.00138421
tremorGyroAmpCoV 0.549714
tremorCoordAmpMean 0.0370795
tremorCoordAmpSlope -0.0010546
tremorCoordAmpCoV 0.335343
tremorAccAmpMean 0.0339235
tremorAccAmpSlope -0.00140074
tremorAccAmpCoV 0.40056
tremorPcRelVar 0.666249
tremorPcX -0.78174
tremorPcY 0.623604

Spiral Segment 1

Duration 76.16 s, Accuracy Estimate 3.72 (lower is better)

Spiral Segment 2

Duration 66.28 s, Accuracy Estimate 3.495 (lower is better)

Elel

eDurationMean 0.639459
eDurationStd 0.172155
eDurationStdnorm 0.269219
eDurationMedian 0.595
eDurationQuartdelta 0.185
eDurationQuartdeltanorm 0.310924
eDurationKurt 4.45113
eDurationTrenddiff -0.165
eDurationTrendratio 0.764286
eWidthMean 3.37086
eWidthStd 1.4835
eWidthStdnorm 0.440094
eWidthMedian 3.042
eWidthQuartdelta 1.521
eWidthQuartdeltanorm 0.5
eWidthKurt 7.21484
eWidthTrenddiff 0
eWidthTrendratio 1
eHeightMean 5.38516
eHeightStd 1.9538
eHeightStdnorm 0.362811
eHeightMedian 5.148
eHeightQuartdelta 2.223
eHeightQuartdeltanorm 0.431818
eHeightKurt 5.15604
eHeightTrenddiff 1.3455
eHeightTrendratio 1.31944
eAspectMean 0.634148
eAspectStd 0.157049
eAspectStdnorm 0.247654
eAspectMedian 0.607143
eAspectQuartdelta 0.257901
eAspectQuartdeltanorm 0.424778
eAspectKurt 2.30679
eAspectTrenddiff -0.160133
eAspectTrendratio 0.76902
eSlantMean -0.00328531
eSlantStd 0.287767
eSlantStdnorm -87.5922
eSlantMedian 0
eSlantQuartdelta 0.292977
eSlantQuartdeltanorm -89.1779
eSlantKurt 3.90906
eSlantTrenddiff -0.0754141
eRtopMean 0.692697
eRtopStd 0.17126
eRtopStdnorm 0.247236
eRtopMedian 0.692308
eRtopQuartdelta 0.22348
eRtopQuartdeltanorm 0.322805
eRtopKurt 3.93618
eRtopTrenddiff -0.133729
eRbotMean 0.727001
eRbotStd 0.35962
eRbotStdnorm 0.494662
eRbotMedian 0.676471
eRbotQuartdelta 0.46192
eRbotQuartdeltanorm 0.682838
eRbotKurt 3.55343
eRbotTrenddiff 0.0667706
eRrightMean 0.810166
eRrightStd 0.11264
eRrightStdnorm 0.139033
eRrightMedian 0.829787
eRrightQuartdelta 0.123891
eRrightQuartdeltanorm 0.149305
eRrightKurt 2.44202
eRrightTrenddiff -0.0219935
eRleftMean 0.407865
eRleftStd 0.190163
eRleftStdnorm 0.466241
eRleftMedian 0.387097
eRleftQuartdelta 0.249851
eRleftQuartdeltanorm 0.645449
eRleftKurt 2.8463
eRleftTrenddiff 0.00620651
lDurationMean 1.13057
lDurationStd 0.317969
lDurationStdnorm 0.281246
lDurationMedian 1.115
lDurationQuartdelta 0.35625
lDurationQuartdeltanorm 0.319507
lDurationKurt 3.33847
lDurationTrenddiff -0.365
lDurationTrendratio 0.718147
lWidthMean 7.56154
lWidthStd 2.00996
lWidthStdnorm 0.265813
lWidthMedian 6.903
lWidthQuartdelta 2.574
lWidthQuartdeltanorm 0.372881
lWidthKurt 3.32762
lWidthTrenddiff -1.989
lWidthTrendratio 0.757143
lHeightMean 16.4736
lHeightStd 3.72976
lHeightStdnorm 0.226408
lHeightMedian 15.561
lHeightQuartdelta 4.095
lHeightQuartdeltanorm 0.263158
lHeightKurt 4.73018
lHeightTrenddiff -3.627
lHeightTrendratio 0.796053
lAspectMean 0.461945
lAspectStd 0.0708283
lAspectStdnorm 0.153326
lAspectMedian 0.469027
lAspectQuartdelta 0.0883
lAspectQuartdeltanorm 0.188262
lAspectKurt 2.58966
lAspectTrenddiff -0.0407076
lAspectTrendratio 0.915228
lSlantMean 0.179732
lSlantStd 0.12192
lSlantStdnorm 0.678343
lSlantMedian 0.20339
lSlantQuartdelta 0.205394
lSlantQuartdeltanorm 1.00985
lSlantKurt 1.85278
lSlantTrenddiff -0.149021
lRtopMean 0.785204
lRtopStd 0.128929
lRtopStdnorm 0.164198
lRtopMedian 0.787879
lRtopQuartdelta 0.201584
lRtopQuartdeltanorm 0.255856
lRtopKurt 2.04125
lRtopTrenddiff -0.087146
lRbotMean 0.410916
lRbotStd 0.162931
lRbotStdnorm 0.396508
lRbotMedian 0.388889
lRbotQuartdelta 0.242168
lRbotQuartdeltanorm 0.622718
lRbotKurt 2.05427
lRbotTrenddiff 0.0542516
lRrightMean 0.900674
lRrightStd 0.0519305
lRrightStdnorm 0.0576574
lRrightMedian 0.902174
lRrightQuartdelta 0.0581737
lRrightQuartdeltanorm 0.0644817
lRrightKurt 4.05197
lRrightTrenddiff -0.0472155
lRleftMean 0.253494
lRleftStd 0.127766
lRleftStdnorm 0.50402
lRleftMedian 0.235669
lRleftQuartdelta 0.145173
lRleftQuartdeltanorm 0.616005
lRleftKurt 3.54104
lRleftTrenddiff 0.0337883

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

FITTS Short Modified

meanTouchScore 0.839068
sumTouchScores 9.22975
meanMovementTime 1.6695
numTouches 11
undershootPercentage 9.09091
overshootPercentage 18.1818

FITTS Long Modified

meanTouchScore 0.881258
sumTouchScores 7.93132
meanMovementTime 2.12
numTouches 9
undershootPercentage 11.1111
overshootPercentage 0

ZigZag

numZigzags 4
timePerZigzagMean 61.5
timePerZigzagCoV 0.0605251
timePerZigzagSlope -0.0251057
meanError 1.89592
tremorFreq 5.95703
tremorRelPower 27.3399
tremorGyroAmpMean 0.0620717
tremorGyroAmpSlope 0.00257058
tremorGyroAmpCoV 0.543834
tremorCoordAmpMean 0.0563158
tremorCoordAmpSlope 0.00229854
tremorCoordAmpCoV 0.39774
tremorAccAmpMean 0.0539972
tremorAccAmpSlope 0.00230079
tremorAccAmpCoV 0.451411
tremorPcRelVar 0.643643
tremorPcX -0.821564
tremorPcY 0.570117

ZigZag Segment 1

Duration 65.08 s, Accuracy Estimate 2.091 (lower is better)

ZigZag Segment 2

Duration 62.6 s, Accuracy Estimate 1.569 (lower is better)

ZigZag Segment 3

Duration 56.28 s, Accuracy Estimate 1.726 (lower is better)

ZigZag Segment 4

Duration 62.04 s, Accuracy Estimate 2.199 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 24.864
timePerZigzagCoV 0.413897
timePerZigzagSlope -0.18388
zigzagHeightMean 65.4828
zigzagHeightCoV 0.0699708
zigzagHeightSlope -0.0133663
meanError 0.0612409
tremorFreq 6.15234
tremorRelPower 25.8864
tremorGyroAmpMean 0.0532052
tremorGyroAmpSlope 0.0016432
tremorGyroAmpCoV 0.519072
tremorCoordAmpMean 0.0806997
tremorCoordAmpSlope 0.00482353
tremorCoordAmpCoV 0.393661
tremorAccAmpMean 0.0979179
tremorAccAmpSlope 0.0023431
tremorAccAmpCoV 0.192562
tremorPcRelVar 0.649667
tremorPcX 0.650817
tremorPcY -0.759235

ZigZag Offset Segment 1

Duration 31.2 s, Accuracy Estimate 0.072 (lower is better)

ZigZag Offset Segment 2

Duration 39.24 s, Accuracy Estimate 0.065 (lower is better)

ZigZag Offset Segment 3

Duration 19.24 s, Accuracy Estimate 0.069 (lower is better)

ZigZag Offset Segment 4

Duration 13.36 s, Accuracy Estimate 0.043 (lower is better)

ZigZag Offset Segment 5

Duration 21.28 s, Accuracy Estimate 0.057 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.8}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.67}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.9731273723167881}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8991571799092186}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.8720298267216064}